Buy increlex
Generic Name: mecasermin (ME ka SER min)
Brand Names: Increlex
Increlex (mecasermin) is a man-made form of insulin-like growth factor-1 (IGF-1), a substance that is normally produced in the body. IGF-1 is important for the growth of bones and muscles. Click here for more info
Important information
Increlex should not be given to a child who has cancer, or a child who has finished growing (the bone growth plates are closed).
Increlex is not for use in children who have growth hormone deficiency, malnutrition, underactive thyroid, or those who are taking long-term steroid medications. Click here for more info
Before your child receives this medicine, tell the doctor if your child has diabetes, kidney disease, liver disease, a curved spine (scoliosis), or if the child has ever had an allergic reaction to a preservative called benzyl alcohol.
Increlex injected under the skin. You can also show and teach your kids how to use this injection at home . Make sure you fully kwon how to administer the injection and properly dispose of used needles and syringes.
Pharmacotherapeutic group
Pituitary and hypothalamic hormones and analogues
Therapeutic indication
For the long-term treatment of growth failure in children and adolescents with severe primary insulin-like-growth-factor-1 deficiency (primary IGFD).
Severe primary IGFD is defined by:
- height standard deviation score ? -3.0 and;
- basal insulin-like growth factor-1 (IGF-1) levels below the 2.5th percentile for age and gender and;
- growth hormone (GH) sufficiency;
- exclusion of secondary forms of IGF-1 deficiency, such as malnutrition, hypothyroidism, or chronic treatment with pharmacologic doses of anti-inflammatory steroids.
Severe primary IGFD includes patients with mutations in the GH receptor (GHR), post-GHR signalling pathway, and IGF-1 gene defects; they are not GH deficient, and therefore, they cannot be expected to respond adequately to exogenous GH treatment. It is recommended to confirm the diagnosis by conducting an IGF-1 generation test.
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