PREDEF 2X – 100 ML

BUY PREDEF 2X – 100 ML

Buy Predef 2X (isoflupredone acetate) Sterile Aqueous Suspension is indicated for Musculoskeletal Conditions: As with other adrenal steroids, this preparation has been found useful in alleviating the pain and lameness associated with generalized and acute localized arthritic conditions in large animals.

Medicinal ingredient: Each mL contains: isoflupredone acetate 2 mg.

Non-medicinal ingredients: sodium citrate 4.5 mg; polyethylene glycol 120 mg; polyvinylpyrrolidone 1 mg; myristyl-gamma-picolinium chloride (as preservative) 0.2 mg and water for injection q.s. When necessary, pH was adjusted with hydrochloric acid and/or sodium hydroxide. Predef 2X is intended for intramuscular or intrasynovial injection in animals and is indicated in situations requiring glucocorticoid, anti-inflammatory, and/or supportive effect.

Metabolic And Hormonal Effects

PREDEF 2X, a potent corticosteroid, has greater glucocorticoid activity than an equal quantity of prednisolone.

The glucocorticoid activity of PREDEF 2X is approximately 10 times that of prednisolone, 50 times that of hydrocortisone, and 67 times that of cortisone as measured by liver glycogen deposition in rats. The gluconeogenic activity is borne out by its hyperglycemic effect in both normal and ketotic cattle.

Predef 2X Indications

Bovine Ketosis. PREDEF 2X, by its gluconeogenic and glycogen deposition activity, is an effective and valuable treatment for the endocrine and metabolic imbalance of primary bovine ketosis. The stresses of parturition and high milk production predispose the dairy cow to this condition. This adrenal steroid causes a prompt physiological effect, with blood glucose levels returning to normal or above within 8 to 24 hours following injection. There is a decrease in circulating eosinophils, followed by a reduction in blood and urine ketones. Usually the general attitude of the cow is much improved, appetite returns, and milk production rises to previous levels within 3 to 5 days. In secondary bovine ketosis, where the condition is complicated by pneumonia, mastitis, endometritis, traumatic gastritis, etc, PREDEF 2X should be used concurrently with proper local and parenteral antibacterial therapy, infusion solutions, and other accepted treatments for the primary conditions.

Musculoskeletal Conditions. As with other adrenal steroids, this preparation has been found useful in alleviating the pain and lameness associated with generalized and acute localized arthritic conditions in large animals. PREDEF 2X has been used successfully to treat laminitis, rheumatoid and traumatic arthritis, osteoarthritis, periostitis, tendinitis, tenosynovitis, bursitis, and myositis. Generalized muscular soreness, stiffness, depression, and anorexia resulting from overwork, shipping, unusual physical exertion, etc, respond promptly. Remission of symptoms may be permanent, or symptoms may recur, depending on the cause and extent of structural degeneration.

Allergic Reactions. PREDEF 2X is especially beneficial in treating acute hypersensitivity reactions resulting from treatment with a sensitizing drug or exposure to other allergenic agents. Usual manifestations are anaphylactoid reactions and urticaria. Less severe allergic manifestations, such as atopic and contact dermatitis, summer eczema, and conjunctivitis, may also be treated. Response is usually rapid and complete, although in severe cases with extensive lesions, more prolonged adrenocorticoid therapy and other appropriate treatment may be indicated.

Overwhelming Infections with Severe Toxicity. In animals moribund from overwhelmingly severe infections for which specific antibacterial therapy is available (eg, critical pneumonia, peritonitis, endometritis, septic mastitis), intensive PREDEF 2X therapy may aid in correcting the circulatory defect by counteracting the responsible inflammatory changes, thereby permitting the antibacterial agent to exert its full effect. As supportive therapy, this steroid combats the stress and improves the general attitude of the animal being treated. All necessary procedures for the establishment of a bacterial diagnosis should be carried out whenever possible before institution of therapy. PREDEF 2X therapy in the presence of infection should be administered for the shortest possible time compatible with maintenance of an adequate response, and antibacterial therapy should be continued for at least three days after the hormone has been withdrawn. Combined hormone and antibacterial therapy does not obviate the need for indicated surgical treatment.